結論

據我們所知，這是第(di)一個全面的(de)(de)研(yan)究，清楚(chu)地顯示了(le)類藥物(wu)化(hua)合(he)物(wu)的(de)(de)內(nei)在(zai)(zai)表面性質(zhi)對生物(wu)相(xiang)關介(jie)質(zhi)中(zhong)溶解(jie)度增(zeng)(zeng)強的(de)(de)影(ying)響，而不是在(zai)(zai)水介(jie)質(zhi)中(zhong)。這項研(yan)究表明，臨界膠(jiao)(jiao)(jiao)束(shu)濃(nong)度（描述(shu)化(hua)合(he)物(wu)在(zai)(zai)膠(jiao)(jiao)(jiao)束(shu)中(zhong)自締合(he)的(de)(de)內(nei)在(zai)(zai)能力）比公認的(de)(de)親脂性更好地預(yu)測FaSSIF中(zhong)的(de)(de)溶解(jie)度增(zeng)(zeng)強。我們的(de)(de)研(yan)究表明，考慮到化(hua)合(he)物(wu)在(zai)(zai)膠(jiao)(jiao)(jiao)束(shu)中(zhong)結合(he)的(de)(de)趨勢，藥物(wu)優化(hua)策略將潛在(zai)(zai)地受(shou)益，作為增(zeng)(zeng)加(jia)腸道(dao)吸收的(de)(de)一種方(fang)式。

作者信息

通訊作者

*電(dian)話：+41616881941。傳真：+41616882908。電(dian)子郵件：魯本。阿爾(er)瓦雷斯_ sanchez roche.com.

筆記

作者聲明沒(mei)有相互競(jing)爭的經濟利(li)益。

致謝

作者(zhe)要感謝比約恩·瓦格納、維吉尼·米卡列夫、伊莎貝爾·帕里(li)拉(la)和(he)薩賓·皮塔(ta)提供(gong)的(de)技術援(yuan)助，以及弗蘭茲·舒勒、薩拉(la)·貝利和(he)喬(qiao)恩·凱爾·博德納爾對(dui)手稿的(de)修訂(ding)和(he)寶貴意見(jian)。

縮寫

FaSSIF，禁食狀態(tai)模擬腸液；FeSSIF，喂食狀態(tai)模擬腸液；臨界膠束(shu)濃(nong)度(du)；生物制藥分類系統；SE，溶解度(du)增(zeng)強(qiang)；logd，辛醇(chun)/水分配系數；電(dian)離常數

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